--001a113e37a6a4b0de0564b9ac2b Content-Type: text/plain; charset="UTF-8" Content-Transfer-Encoding: quoted-printable Hi Karine, Please translate the following article. I will send another one over tomorrow. Thanks! New Research Suggests Alzheimer=E2=80=99s Starts Outside of the BrainPosted= on December 18, 2017 Gina Roberts-Grey VIEW BIO For over two decades, Gina Roberts-Grey has pored over studies and interviewed leading health experts on topics ranging from healthy aging, caregiving and longevity. Having been an active caregiver to her grandparents who lived into their 90=E2=80=99s, Gina is passionate about su= pporting caregivers through their journeys. Her work has been featured in publications like Woman's Day, AARP, Oprah, Neurology Now and many more. [image: twenty20_4f8ba3e9-ebb2-4f9a-8782-075803f15699] *Learn how studies indicate that the whole body impacts a healthy brain and one=E2=80=99s susceptibility to Alzheimer=E2=80=99s* More than five million Americans are living with Alzheimer=E2=80=99s diseas= e, the progressive neurological condition that destroys eats away at memories and other brain functions. And while its symptoms, like memory loss, all center in the brain, experts are beginning to look at how the disease may begin in other parts of the body. And these new theories may open the door to new and innovative options for potential prevention and treatment. *It=E2=80=99s not all in your head* Alzheimer=E2=80=99s disease presents researchers with what some call a =E2= =80=9Cwhich comes first=E2=80=9D problem.1 =E2=80=9CThere are two main changes in the brain a= ssociated with Alzheimer=E2=80=99s: synaptic tangles and amyloid plaques. We used to think= the plaques lead to tangles that trigger the breakdown of neurons in the brain. Now, we=E2=80=99re not sure which process is first,=E2=80=9D says James Gio= rdano, Ph.D. professor of neurology and biochemistry and Chief, Neuroethics Studies Program, at Georgetown University Medical Center. But Giordano says scientists are beginning to understand the process of =E2=80=9Cinflammaging=E2=80=9D or the inflammatory process throughout the b= ody that occurs and ramps up as we age, can penetrate the brain, bringing about a cascade of reactions that lead to plaques and tangles associated with the early signs of Alzheimer=E2=80=99s . =E2=80=9COne of the most damaging processes in the body is a long standing inflammatory state throughout your life,=E2=80=9D says Giordano. =E2=80=9CM= any chemicals associated with inflammation in the body can penetrate the brain to induce an inflammatory state and that becomes a problem.=E2=80=9D That inflammation can come from having Type 2 diabetes, being overweight or obese or having peripheral cardiovascular disease like atherosclerosis. These health issues cause dysfunction in part of the mitochondria, the power of every cell in the body, which can lead to a build-up of reactive chemicals that damage cell membranes.1 =E2=80=9CThese reactions outside of